With a few exceptions, most ergonomic keyboards will work with PCs or Macs as a standard typing input, but the use of function and hot keys may require some remapping. It can be as easy as an onboard switch to toggle between Mac and PC layouts, or as involved as downloading software to change up the keys. Some boards even include (or let you buy) extra keycaps to change, say, the Mac’s Command and Option keys to PC’s Start and Alt buttons. Those are what's called hot-swappable keys, meaning you just pull the old key off (usually with a provided key puller) and stick the new one on, no soldering required.
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Source: Computational Materials Science, Volume 267
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